Rotherham United and Barnsley take on London-based clubs on Tuesday night, with the former travelling to Queens Park Rangers and the latter taking on Brentford at Oakwell in the Championship.
The Millers were defeated last time out and can count themselves as fortunate to only concede one goal against Swansea City.
Matt Grimes fired in the winner midway through the first half, striking the ball from the edge of the box after a Swans corner.
Opponents, QPR, drew 1-1 with promotion-chasing Watford on Saturday at the Kiyan Prince Foundation Stadium.
Watford defender Ben Wilmot opened the scoring after just three minutes, but Illias Chair managed to grab an equaliser with just 13 minutes remaining of the match.
Rotherham are looking to win three consecutive away league matches in London for the first time since September 2010 and are looking to record consecutive league wins over QPR for the first time since March 1952.
The Tykes host West Londoners, Brentford, as they look to continue their rise up the table.
Barnsley won 2-0 at Oakwell on Saturday, with late goals from Callum Styles and Cauley Woodrow against Nottingham Forest.
It has been a rough few games for the Bees, drawing their last three Championship matches and only scoring one goal in the process.
Barnsley are looking to win back-to-back league matches against Brentford for the first time since April 2003, whilst Brentford have not won back-to-back league visits to Barnsley since August 1959, winning 3-1 in this exact fixture last season.
Finally, on Tuesday evening, Doncaster Rovers face Blackpool at the Keepmoat Stadium in the Championship.
Fejiri Okenabirhie equalised deep into stoppage time at the weekend in their 1-1 draw with Sunderland, after Grant Leadbitter’s thunderbolt gave the Black Cats the lead.
Opponents, Blackpool, also benefited from a late goal on Saturday, with striker Gary Madine netting in the 90th minute to seal the points against Peterborough United.
Rovers have won just one of their last 11 home league games against Blackpool (D4 L6), winning 2-0 in November 2018 but they have only lost one of their previous 10 home games in League One (W6 D3), despite only keeping one clean sheet in this run.
Sheffield Wednesday travel to South Wales on Wednesday night to face Swansea City in the Championship.
New Owls boss, Tony Pulis, will be hoping for his first win as Wednesday manager after suffering defeat in his first match in charge against Preston North End, thanks to a superb Tom Barkhuizen volley.
Wednesday will be without Josh Windass after he was sent off against the Lilywhites but will be hoping to have Dominic Iorfa back fit after he was absent from the squad due to injury.
The Owls will be hoping not to receive the same fait as Rotherham, who lost 1-0 on Saturday to the Swans.
Pulis has never won away to Swansea City in a league match in his managerial career (P8 D2 L6), failing with Bournemouth, Stoke, Crystal Palace, West Brom and Middlesbrough.
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